Cutting Edge: Bacterial Lipoprotein Induces Endotoxin-Independent Tolerance to Septic Shock

Cutting Edge: Bacterial Lipoprotein Induces

Identification of Biomarkers of Response to IFNg during Endotoxin Tolerance: Application to Septic Shock

The rapid development in septic patients of features of marked immunosuppression associated with increased risk of nosocomial infections and mortality represents the rational for the initiation of immune targeted treatments in sepsis. However, as there is no clinical sign of immune dysfunctions, the current challenge is to develop biomarkers that will help clinicians identify the patients that ...

Cutting Edge: Lipopolysaccharide Induces

Cutting Edge: Lipopolysaccharide Induces

Passive Transfer of Tolerance to Pyrogenicity of Bacterial Endotoxin

The typical febrile response of normal rabbits given bacterial endotoxin intravenously may be modified by prior administration of plasma or, less effectively, serum of endotoxin-tolerant donors. This altered response is characterized by disappearance of the second rise in fever and by a striking reduction in fever index. It thus resembles the course of fever shown by rabbits made tolerant to en...